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GW 284543 hydrochloride
CAS No. 179246-08-3
GW 284543 hydrochloride( —— )
Catalog No. M20933 CAS No. 179246-08-3
GW 284543 hydrochloride is a selective inhibitor of MEK5 .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 61 | Get Quote |
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| 5MG | 86 | Get Quote |
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| 10MG | 156 | Get Quote |
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| 25MG | 300 | Get Quote |
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| 50MG | 510 | Get Quote |
|
| 100MG | 698 | Get Quote |
|
| 200MG | 897 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGW 284543 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionGW 284543 hydrochloride is a selective inhibitor of MEK5 .
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DescriptionGW 284543 hydrochloride is a selective inhibitor of MEK5 .
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In VitroGW284543 (10 and 20 μM; 6 h) treatment inhibits MEK5 in a dose-dependent manner and reduces pERK5. Western Blot Analysis Cell Line:MIA PaCa-2 cells Concentration:10 and 20 μM Incubation Time:6 hours Result:Reduced phosphorylation of ERK5, and decreased endogenous MYC protein.
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetMEK
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RecptorMEK5
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Research Area——
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Indication——
Chemical Information
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CAS Number179246-08-3
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Formula Weight408.87
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Molecular FormulaC23H21ClN2O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCOc1cc2nccc(Nc3cccc(Oc4ccccc4)c3)c2cc1OC.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Vaseva AV Blake DR Gilbert TSKet al.KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism[J].Cancer Cell. 2018 Nov 12;34(5):807-822.e7.
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